Transient tone anomalies in very preterm infants: Association with term-equivalent brain magnetic resonance imaging and neurodevelopment at 18 months.

Détails

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Etat: Public
Version: de l'auteur⸱e
Licence: Non spécifiée
ID Serval
serval:BIB_B815A29BF09D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Transient tone anomalies in very preterm infants: Association with term-equivalent brain magnetic resonance imaging and neurodevelopment at 18 months.
Périodique
Early human development
Auteur⸱e⸱s
Brunner P., Schneider J., Borradori-Tolsa C., Bickle-Graz M., Hagmann P., Macherel M., Huppi P.S., Truttmann A.C.
ISSN
1872-6232 (Electronic)
ISSN-L
0378-3782
Statut éditorial
Publié
Date de publication
04/2020
Peer-reviewed
Oui
Volume
143
Pages
104998
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Very preterm (VPT) infants are at risk for neurodevelopmental impairments and early clinical findings such as transient tone anomalies (TTA) might represent potential predictive indicators.
The aims of this study were to assess 1) the prevalence of TTA at 6 months corrected age in a population of VPT infants, 2) the association with term-equivalent age (TEA) brain MRI and 3) the neurodevelopmental outcome at 18 months corrected age.
A prospective case-control cohort of 103 VPT infants (<29 weeks of gestation) was followed up at 6 months and classified into TTA+ or TTA-. TTA+ was defined by the presence of ≥2 criteria among anomalies of posture, anomalies of tone and hyperreflexia.
Conventional and diffusion-weighted MRIs at TEA were analyzed according to a semi-quantitative MRI scoring system and apparent diffusion coefficients (ADC) and fractional anisotropy (FA) were measured in frontal, occipital white matter and posterior limb of the internal capsule (PLIC). Neurodevelopment was assessed at 18 months using Bayley-II scales (Psychomotor Developmental Index: PDI; Mental Developmental Index: MDI).
TTA+ infants represented 29.1% of the total population. They had: 1) significantly higher ADC values in 3 regions of interest (p < 0.001), 2) significant lower FA in the PLIC (p < 0.001), and 3) significant lower PDI score (p < 0.05). No differences were observed regarding MDI scores. Interaction of TTA by cerebellum score was related to lower MDI scores.
In VPT infants, TTA at 6 months and/or structural brain abnormality at TEA are associated with poorer neurodevelopmental outcome at 18 months.
Mots-clé
Brain/diagnostic imaging, Dystonic Disorders/epidemiology, Female, Humans, Infant, Infant, Extremely Premature/growth & development, Infant, Extremely Premature/physiology, Infant, Newborn, Infant, Premature, Diseases/epidemiology, Magnetic Resonance Imaging, Male, Neurodevelopmental Disorders/epidemiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/03/2020 15:31
Dernière modification de la notice
28/02/2024 7:14
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