A common biological basis of obesity and nicotine addiction.

Details

Serval ID
serval:BIB_B81330AE7F71
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A common biological basis of obesity and nicotine addiction.
Journal
Translational Psychiatry
Author(s)
Thorgeirsson T.E., Gudbjartsson D.F., Sulem P., Besenbacher S., Styrkarsdottir U., Thorleifsson G., Walters G.B., Furberg H., Furberg H., Sullivan P.F., Marchini J., McCarthy M.I., Steinthorsdottir V., Thorsteinsdottir U., Stefansson K.
Working group(s)
TAG Consortium, Oxford-GSK Consortium, ENGAGE consortium
Contributor(s)
Kim YJ., Dackor J., Boerwinkle E., Franceschini N., Ardissino D., Bernardinelli L., Mannucci PM., Mauri F., Merlini PA., Absher D., Assimes TL., Fortmann SP., Iribarren C., Knowles JW., Quertermous T., Ferrucci L., Tanaka T., Bis JC., Furberg CD., Haritunians T., McKnight B., Psaty BM., Taylor KD., Thacker EL., Almgren P., Groop L., Ladenvall C., Boehnke M., Jackson AU., Mohlke KL., Stringham HM., Tuomilehto J., Benjamin EJ., Hwang SJ., Levy D., Preis SR., Vasan RS., Duan J., Gejman PV., Levinson DF., Sanders AR., Shi J., Lips EH., McKay JD., Agudo A., Barzan L., Bencko V., Benhamou S., Castellsagué X., Canova C., Conway DI., Fabianova E., Foretova L., Janout V., Healy CM., Holcátová I., Kjaerheim K., Lagiou P., Lissowska J., Lowry R., Macfarlane TV., Mates D., Richiardi L., Rudnai P., Szeszenia-Dabrowska N., Zaridze D., Znaor A., Lathrop M., Brennan P., Bandinelli S., Frayling TM., Guralnik JM., Milaneschi Y., Perry JR., Altshuler D., Elosua R., Kathiresan S., Lucas G., Melander O., O'Donnell CJ., Salomaa V., Schwartz SM., Voight BF., Penninx BW., Smit JH., Vogelzangs N., Boomsma DI., de Geus EJ. , Vink JM., Willemsen G., Chanock SJ., Gu F., Hankinson SE., Hunter DJ., Hofman A., Tiemeier H., Uitterlinden AG., van Duijn CM. , Walter S., Chasman DI., Everett BM., Paré G., Ridker PM., Li MD., Maes HH., Audrain-McGovern J., Posthuma D., Thornton LM., Lerman C., Kaprio J., Rose JE., Ioannidis JP., Kraft P., Lin DY., Liu JS., Tozzi F., Waterworth DM., Pillai SG., Muglia P., Middleton L., Berrettini W., Knouff CW., Yuan X., Waeber G., Vollenweider P., Preisig M., Wareham NJ., Zhao JH., Loos RJ., Barroso£££Inês£££ I. , Khaw KT., Grundy S., Barter P., Mahley R., Kesaniemi A., McPherson R., Vincent J., Strauss J., Kennedy J., Farmer A., McGuffin P., Day R., Matthews K., Bakke P., Gulsvik A., Lucae S., Ising M., Brueckl T., Horstmann S., Heinrich J., Rawal R., Dahmen N., Lamina C., Polasek O., Zgaga L., Huffman J., Campbell S., Kooner J., Chambers JC., Burnett MS., Devaney J., Pichard AD., Kent KM., Satler L., Lindsay JM., Waksman R., Epstein S., Wilson JF., Wild SH., Campbell H., Vitart V., Reilly MP., Li M., Qu L., Wilensky R., Matthai W., Hakonarson HH., Rader DJ., Franke A., Wittig M., Schäfer A., Uda M., Terracciano A., Xiao X., Busonero F., Scheet P., Schlessinger D., St Clair D., Rujescu D., Abecasis GR., Grabe HJ., Teumer A., Völzke H., Petersmann A., John U., Rudan I., Hayward C., Wright AF., Kolcic I., Wright BJ., Thompson JR., Balmforth AJ., Hall AS., Samani NJ., Anderson CA., Ahmed T., Mathew CG., Parkes M., Satsangi J., Caulfield M., Munroe PB., Farrall M., Dominiczak A., Worthington J., Thomson W., Eyre S., Barton A., Mooser V., Francks C., Surakka I., Vink JM., Amin N., Geller F., Rafnar T., Esko£££Tõnu£££ T. , Walter S., Gieger C., Rawal R., Mangino M., Prokopenko I., Mägi R., Keskitalo K., Gudjonsdottir IH., Gretarsdottir S., Stefansson H., Aulchenko YS., Nelis M., Aben KK., den Heijer M., Soranzo N., Valdes AM., Steves C., Uitterlinden AG., Hofman A., Tönjes A., Kovacs P., Hottenga JJ., Willemsen G., Vogelzangs N., Döring A., Dahmen N., Nitz B., Ripatti S., Perola M., Kettunen J., Hartikainen AL., Pouta A., Laitinen J., Isohanni M., Huei-Yi S., Allen M., Krestyaninova M., Hall AS., Thompson JR., Oskarsson H., Tyrfingsson T., Kiemeney LA., Järvelin MR., Salomaa V., Stumvoll M., Spector TD., Wichmann HE., Metspalu A., Samani NJ., Penninx BW., Oostra BA., Boomsma DI., Tiemeier H., van Duijn CM. , Kaprio J., Gulcher JR.
ISSN
2158-3188 (Electronic)
ISSN-L
2158-3188
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
3
Pages
e308
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: epublish
Abstract
Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked per day (CPD) in an Icelandic sample (N=34,216 smokers). Combined according to their effect on BMI, the SNPs correlate with both SI (r=0.019, P=0.00054) and CPD (r=0.032, P=8.0 × 10(-7)). These findings replicate in a second large data set (N=127,274, thereof 76,242 smokers) for both SI (P=1.2 × 10(-5)) and CPD (P=9.3 × 10(-5)). Notably, the variant most strongly associated with BMI (rs1558902-A in FTO) did not associate with smoking behavior. The association with smoking behavior is not due to the effect of the SNPs on BMI. Our results strongly point to a common biological basis of the regulation of our appetite for tobacco and food, and thus the vulnerability to nicotine addiction and obesity.
Pubmed
Web of science
Open Access
Yes
Create date
16/01/2014 16:08
Last modification date
20/08/2019 15:26
Usage data