The paracaspase MALT1: biological function and potential for therapeutic inhibition.

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State: Public
Version: Final published version
Serval ID
serval:BIB_B68EA67B0DAA
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The paracaspase MALT1: biological function and potential for therapeutic inhibition.
Journal
Cellular and Molecular Life Sciences
Author(s)
Jaworski M., Thome M.
ISSN
1420-9071 (Electronic)
ISSN-L
1420-682X
Publication state
Published
Issued date
2016
Volume
73
Number
3
Pages
459-473
Language
english
Abstract
The paracaspase MALT1 has a central role in the activation of lymphocytes and other immune cells including myeloid cells, mast cells and NK cells. MALT1 activity is required not only for the immune response, but also for the development of natural Treg cells that keep the immune response in check. Exaggerated MALT1 activity has been associated with the development of lymphoid malignancies, and recently developed MALT1 inhibitors show promising anti-tumor effects in xenograft models of diffuse large B cell lymphoma. In this review, we provide an overview of the present understanding of MALT1's function, and discuss possibilities for its therapeutic targeting based on recently developed inhibitors and animal models.
Keywords
Amino Acid Motifs, Animals, B-Lymphocytes/metabolism, B-Lymphocytes/physiology, Caspases/metabolism, Caspases/physiology, Humans, Immunomodulation/genetics, Killer Cells, Natural/metabolism, Killer Cells, Natural/physiology, Lymphoma, Large B-Cell, Diffuse/genetics, Models, Molecular, NF-kappa B/metabolism, NF-kappa B/physiology, Neoplasm Proteins/antagonists & inhibitors, Neoplasm Proteins/metabolism, RNA Stability, RNA, Messenger/metabolism, Transcription Factor AP-1/metabolism, Transcription Factor AP-1/physiology
Pubmed
Web of science
Open Access
Yes
Create date
02/02/2016 13:35
Last modification date
20/08/2019 15:24
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