Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus

Details

Serval ID
serval:BIB_B5D84C87DE39
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus
Journal
Journal of Experimental Medicine
Author(s)
Speiser  D. E., Lees  R. K., Hengartner  H., Zinkernagel  R. M., MacDonald  H. R.
ISSN
0022-1007 (Print)
Publication state
Published
Issued date
12/1989
Volume
170
Number
6
Pages
2165-70
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec 1
Abstract
The role of thymic MHC class II-bearing cells in the selection of the TCR repertoire has been investigated in allogeneic radiation bone marrow chimeras. Positive selection of mature CD4+ T lymphocytes expressing the V beta 6+ TCR domain was found to depend upon radioresistant (presumably epithelial) I-E+ thymic cells. On the other hand, negative selection of CD4+ V beta 6+ cells (which was additionally dependent upon expression of the Mls-1a gene product) was controlled by a radiosensitive I-E+ thymic component (most likely dendritic cells). These data argue in favor of a compartmentalization of positive and negative selection events during T cell development.
Keywords
Animals Antigens, Surface/genetics H-2 Antigens/genetics Mice Mice, Inbred DBA Minor Lymphocyte Stimulatory Antigens Radiation Tolerance Receptors, Antigen, T-Cell/*physiology T-Lymphocytes/physiology Thymus Gland/*immunology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 11:32
Last modification date
20/08/2019 15:24
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