Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus
Details
Serval ID
serval:BIB_B5D84C87DE39
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus
Journal
Journal of Experimental Medicine
ISSN
0022-1007 (Print)
Publication state
Published
Issued date
12/1989
Volume
170
Number
6
Pages
2165-70
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec 1
Research Support, Non-U.S. Gov't --- Old month value: Dec 1
Abstract
The role of thymic MHC class II-bearing cells in the selection of the TCR repertoire has been investigated in allogeneic radiation bone marrow chimeras. Positive selection of mature CD4+ T lymphocytes expressing the V beta 6+ TCR domain was found to depend upon radioresistant (presumably epithelial) I-E+ thymic cells. On the other hand, negative selection of CD4+ V beta 6+ cells (which was additionally dependent upon expression of the Mls-1a gene product) was controlled by a radiosensitive I-E+ thymic component (most likely dendritic cells). These data argue in favor of a compartmentalization of positive and negative selection events during T cell development.
Keywords
Animals
Antigens, Surface/genetics
H-2 Antigens/genetics
Mice
Mice, Inbred DBA
Minor Lymphocyte Stimulatory Antigens
Radiation Tolerance
Receptors, Antigen, T-Cell/*physiology
T-Lymphocytes/physiology
Thymus Gland/*immunology
Pubmed
Web of science
Open Access
Yes
Create date
28/01/2008 12:32
Last modification date
20/08/2019 16:24