International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis.

Details

Serval ID
serval:BIB_B539AD0B6ECF
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis.
Journal
JAMA dermatology
Author(s)
van Huizen A.M., Menting S.P., Gyulai R., Iversen L., van der Kraaij G.E., Middelkamp-Hup M.A., Warren R.B., Spuls P.I., Schejtman A.A., Egeberg A., Firooz A., Kumar A.S., Oakley A., Foulkes A., Ramos AMC, Fougerousse A.C., Carija A., Akman-Karakas A., Horváth B., Fábos B., Matlock B.H., Claréus B.W., Castro C., Ferrándiz C., Correa C.C., Marchesi C., Goujon C., Gonzalez C., Maldonado-García C., Hong C.H., Griffiths CEM, Vestergaard C., Echeverría C.M., de la Cruz C., Conrad C., Törocsik D., Drvar D.L., Balak D., Jullien D., Appelen D., Kim D.H., de Jong EMGJ, El Gamal E., Laffitte E., Mahé E., Sonkoly E., Colombo E.P., Vilarrasa E., Willaert F., Novoa F.D., Handjani F., Valenzuela F., Vílchez-Márquez F., Gonzalez G.O., Krisztián G., Damiani G., Krnjevic-Pezic G., Pellerano G., Carretero G., Hunter HJA, Riad H., Oon H.H., Boonen HPJ, Moussa I.O., García-Doval I., Csányi I., Brajac I., Turchin I., Grozdev I., Weinberg J.M., Nicolopoulos J., Wells J., Lambert JLW, Ingram J.R., Prinz J.C., de Souza Sittart J.A., Sanchez J.L., Hsiao J.P., Castro-Ayarza J.R., Maul J.T., van den Reek JMPA, Trcko K., Barber K., Reich K., Gebauer K.A., Khobzei K., Maul L.V., Massari L.P., Fardet L., le Cleach L., Misery L., Chandrashekar L., Muresanu L.I., Lecluse L., Skov L., Frez M.L., Babic L.T., Puig L., Gomez L.C., Ramam M., Dutil M., El-Sayed M.H., Olszewska M., Schram M.E., Franco M.D., Llamas-Velasco M., Gonçalo M., Velásquez-Lopera M.M., Abad M.E., de Oliveira MFSP, Seyger MMB, Kaštelan M., Rademaker M., Sikora M., Lebwohl M., Wiseman M.C., Ferran M., van Doorn M., Danespazhooh M., Bylaite-Bucinskiene M., Gooderham M.J., Polic M.V., de Rie M.A., Zheng M., Gómez-Flores M., Salleras I Redonnet M., Silverberg N.B., Doss N., Yawalkar N., Chosidow O., Zargari O., de la Cueva P., Fernandez-Peñas P., Cárdenas Rojas P.J., Gisondi P., Grewal P., Sator P., Luna P.C., Félix PAO, Varela P., Holló P., Cetkovska P., Calzavara-Pinton P., Ghislain P.D., Araujo R.R., Romiti R., Kui R., Ceovic R., Vender R., Lafuente-Urrez R.F., Del-Río R., Gulin S.J., Handa S., Mahil S.K., Kolalapudi S.A., Marrón S.E., Azimi S.Z., Janmohamed S.R., da Cruz Costa S.A., Choon S.E., Urbancek S., Ayanlowo O., Margasin S.M., Wong T.W., Mälkönen T., Hurtová T., Reciné T.R., Huldt-Nystrøm T., Torres T., Liu T.Y., Leonidze T., Sharma V.K., Weightman W., Gulliver W., Veldkamp W.
Working group(s)
SPIN MTX Consensus Survey Study Group
ISSN
2168-6084 (Electronic)
ISSN-L
2168-6068
Publication state
Published
Issued date
01/05/2022
Peer-reviewed
Oui
Volume
158
Number
5
Pages
561-572
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide.
To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics.
Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience).
In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree.
Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients.
In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis.
Keywords
Adult, Child, Consensus, Folic Acid, Humans, Methotrexate, Psoriasis/therapy, Surveys and Questionnaires
Pubmed
Web of science
Create date
09/04/2022 19:13
Last modification date
04/11/2023 8:08
Usage data