Sequential high-dose methotrexate and fluorouracil combined with doxorubicin--a step ahead in the treatment of advanced gastric cancer: a trial of the European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cooperative Group.

Details

Serval ID
serval:BIB_B4EC98E0995A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Sequential high-dose methotrexate and fluorouracil combined with doxorubicin--a step ahead in the treatment of advanced gastric cancer: a trial of the European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cooperative Group.
Journal
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Author(s)
Wils J.A., Klein H.O., Wagener D.J., Bleiberg H., Reis H., Korsten F., Conroy T., Fickers M., Leyvraz S., Buyse M., Duez  N.
ISSN
0732-183X (Print)
ISSN-L
0732-183X
Publication state
Published
Issued date
1991
Volume
9
Number
5
Pages
827-831
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Multicenter Study ; Randomized Controlled Trial Publication Status: ppublish
Abstract
In a prospective phase III multicenter trial, 213 patients with advanced measurable or nonmeasurable gastric cancer were randomized to receive methotrexate (MTX), fluorouracil (5-FU), and Adriamycin (doxorubicin; Farmitalia Carlo Erba, Milan, Italy) (FAMTX) or 5-FU, Adriamycin, and mitomycin (FAM). The results show a significantly superior response rate (41% v 9% [P less than .0001]), and survival (median, 42 weeks v 29 weeks [P = .004]) for FAMTX. There was a cumulative thrombocytopenia in FAM and not in FAMTX. The FAMTX protocol should be the reference treatment in future clinical trials that seek to improve the therapeutic outcome in advanced gastric cancer.
Keywords
Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Doxorubicin/administration & dosage, Female, Fluorouracil/administration & dosage, Humans, Male, Methotrexate/administration & dosage, Middle Aged, Neoplasm Staging, Prospective Studies, Remission Induction, Stomach Neoplasms/drug therapy, Stomach Neoplasms/mortality, Survival Analysis
Pubmed
Web of science
Create date
28/01/2008 8:32
Last modification date
20/08/2019 15:23
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