Host genetics of invasive Aspergillus and Candida infections.

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State: Public
Version: Final published version
Serval ID
serval:BIB_B4D8A17056DF
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Host genetics of invasive Aspergillus and Candida infections.
Journal
Seminars in Immunopathology
Author(s)
Wójtowicz A., Bochud P.Y.
ISSN
1863-2300 (Electronic)
ISSN-L
1863-2297
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
37
Number
2
Pages
173-186
Language
english
Notes
Publication types: Journal Article Publication Status: ppublish Document type : review
Abstract
Invasive candidiasis and aspergillosis are major complications in surgical and onco-hematological patients, and still associated with an important morbidity and mortality. A large number of studies highlighted the potential role of host genetic polymorphisms that may influence susceptibility to fungal pathogens, but many were limited by insufficient statistical power, problematic design, and/or lack of replication. However, some relevant polymorphisms are now emerging from well-conducted studies whose associations have been replicated and/or are supported by strong biological evidence. Such polymorphisms together with other biomarkers may play a role in the prediction, diagnosis, and management of severe fungal infections in high-risk patients in the coming years.
Pubmed
Web of science
Create date
13/03/2015 18:20
Last modification date
20/08/2019 15:23
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