Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions.

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Serval ID
serval:BIB_B49BF0611936
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Relaxivity of Gd-based contrast agents on X nuclei with long intrinsic relaxation times in aqueous solutions.
Journal
Magnetic Resonance Imaging
Author(s)
van Heeswijk R.B., Laus S., Morgenthaler F.D., Gruetter R.
ISSN
0730-725X (Print)
ISSN-L
0730-725X
Publication state
Published
Issued date
07/2007
Peer-reviewed
Oui
Volume
25
Number
6
Pages
821-825
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Abstract
The relaxivity of commercially available gadolinium (Gd)-based contrast agents was studied for X-nuclei resonances with long intrinsic relaxation times ranging from 6 s to several hundred seconds. Omniscan in pure 13C formic acid had a relaxivity of 2.9 mM(-1) s(-1), whereas its relaxivity on glutamate C1 and C5 in aqueous solution was approximately 0.5 mM(-1) s(-1). Both relaxivities allow the preparation of solutions with a predetermined short T1 and suggest that in vitro substantial sensitivity gains in their measurement can be achieved. 6Li has a long intrinsic relaxation time, on the order of several minutes, which was strongly affected by the contrast agents. Relaxivity ranged from approximately 0.1 mM(-1) s(-1) for Omniscan to 0.3 for Magnevist, whereas the relaxivity of Gd-DOTP was at 11 mM(-1) s(-1), which is two orders of magnitude higher. Overall, these experiments suggest that the presence of 0.1- to 10-microM contrast agents should be detectable, provided sufficient sensitivity is available, such as that afforded by hyperpolarization, recently introduced to in vivo imaging.
Keywords
Carbon Radioisotopes/pharmacology, Chelating Agents/chemistry, Contrast Media/pharmacology, Formates/chemistry, Gadolinium/pharmacology, Image Processing, Computer-Assisted, Lithium/pharmacology, Magnetic Resonance Imaging/instrumentation, Magnetic Resonance Imaging/methods, Nanoparticles/chemistry, Organometallic Compounds/chemistry, Sensitivity and Specificity, Solutions, Water/chemistry
Pubmed
Web of science
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13/12/2012 16:30
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20/08/2019 15:23
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