Postnatal gender-dependent maturation of cellular cysteine uptake

Details

Serval ID
serval:BIB_B464186FD3DD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Postnatal gender-dependent maturation of cellular cysteine uptake
Journal
Free Radical Research
Author(s)
Lavoie  J. C., Rouleau  T., Truttmann  A. C., Chessex  P.
ISSN
1071-5762 (Print)
Publication state
Published
Issued date
08/2002
Volume
36
Number
8
Pages
811-7
Notes
Journal Article --- Old month value: Aug
Abstract
BACKGROUND: In view of the functional capacity of glutathione synthesis in premature infants, and because the availability of cysteine is one the rate limiting steps in glutathione synthesis, we hypothesized that the low glutathione levels in premature infants may be due to immaturity of the active cellular uptake of cysteine. OBJECTIVE: To document in cells from newborn infants the effect of maturity and gender on cysteine uptake and consequently on glutathione levels. METHODS: Incorporation of L-[35S] cysteine was measured in leukocytes from cord blood and from tracheal aspirates (TAC) of newborn infants of varying (gestational as well as postnatal) ages and gender. Cysteine uptake was correlated with glutathione in TAC. RESULTS: The maturity of newborn girls positively influences cysteine uptake, which is responsible for 78% of the variation in their glutathione content. However, in newborn boys, gestational and postnatal ages did not influence the cysteine uptake. DISCUSSION: Cysteine uptake appears to be the limiting step explaining the reported gender-related differences in glutathione as well as the low levels of this central antioxidant found in premature infants. The immature cysteine uptake found in cells from premature infants raises questions about the bioavailability of this conditionally essential amino acid in regimens of parenteral nutrition for human neonates.
Keywords
Age Factors Antioxidants/metabolism Cysteine/*metabolism/*pharmacokinetics Female Fetal Blood/metabolism Gestational Age Glutathione/metabolism Humans Infant, Newborn Infant, Premature Male Sex Factors Time Factors Trachea/metabolism
Pubmed
Web of science
Create date
28/01/2008 13:50
Last modification date
20/08/2019 15:22
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