Midregional pro-atrial natriuretic peptide and procalcitonin improve survival prediction in VAP.

Details

Serval ID
serval:BIB_B348B3168D7F
Type
Article: article from journal or magazin.
Collection
Publications
Title
Midregional pro-atrial natriuretic peptide and procalcitonin improve survival prediction in VAP.
Journal
European Respiratory Journal
Author(s)
Boeck L., Eggimann P., Smyrnios N., Pargger H., Thakkar N., Siegemund M., Marsch S., Rakic J., Tamm M., Stolz D.
ISSN
1399-3003 (Electronic)
ISSN-L
0903-1936
Publication state
Published
Issued date
2011
Peer-reviewed
Oui
Volume
37
Number
3
Pages
595-603
Language
english
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Ventilator-associated pneumonia (VAP) affects mortality, morbidity and cost of critical care. Reliable risk estimation might improve end-of-life decisions, resource allocation and outcome. Several scoring systems for survival prediction have been established and optimised over the last decades. Recently, new biomarkers have gained interest in the prognostic field. We assessed whether midregional pro-atrial natriuretic peptide (MR-proANP) and procalcitonin (PCT) improve the predictive value of the Simplified Acute Physiologic Score (SAPS) II and Sequential Related Organ Failure Assessment (SOFA) in VAP. Specified end-points of a prospective multinational trial including 101 patients with VAP were analysed. Death <28 days after VAP onset was the primary end-point. MR-proANP and PCT were elevated at the onset of VAP in nonsurvivors compared with survivors (p = 0.003 and p = 0.017, respectively) and their slope of decline differed significantly (p = 0.018 and p = 0.039, respectively). Patients with the highest MR-proANP quartile at VAP onset were at increased risk for death (log rank p = 0.013). In a logistic regression model, MR-proANP was identified as the best predictor of survival. Adding MR-proANP and PCT to SAPS II and SOFA improved their predictive properties (area under the curve 0.895 and 0.880). We conclude that the combination of two biomarkers, MR-proANP and PCT, improve survival prediction of clinical severity scores in VAP.
Keywords
Adult, Aged, Atrial Natriuretic Factor/blood, Biological Markers/metabolism, Calcitonin/blood, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Pneumonia, Ventilator-Associated/mortality, Pneumonia, Ventilator-Associated/therapy, Prospective Studies, Protein Precursors/blood, ROC Curve, Regression Analysis, Risk, Treatment Outcome
Pubmed
Open Access
Yes
Create date
28/01/2011 18:25
Last modification date
20/08/2019 16:21
Usage data