Oxidation and ubiquitination in neurodegeneration.

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State: Public
Version: author
Serval ID
serval:BIB_B27897B2A4E5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Oxidation and ubiquitination in neurodegeneration.
Journal
Experimental Biology and Medicine
Author(s)
Riederer B.M., Leuba G., Elhajj Z.
ISSN
1535-3699 (Electronic)
ISSN-L
1535-3699
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
238
Number
5
Pages
519-524
Language
english
Abstract
It is widely accepted that protein oxidation is involved in a variety of diseases, including neurodegenerative diseases. Especially during aging, a reduction in anti-oxidant defence mechanisms leads to an increased formation of free radical oxygen species and consequently results in a damage of proteins, including mitochondrial and synaptic ones. Even those proteins involved in repair and protein clearance via the ubiquitin proteasome and lysosomal system are subject to damage and show a reduced function. Here, we will discuss a variety of mechanisms and provide examples where cognition is affected and where repair mechanisms are no longer sufficient to compensate for a dysfunction of damaged proteins or even may become toxic. Next to physiological deficits, an accumulation of deficient proteins in aggresomes may occur and result in a formation of pathological hallmark structures typical for aging and disease. A major challenge is how to prevent aberrant oxidation, given that oxidation plays an essential role in aging and neurodegenerative diseases. Particularly interesting are the possibilities to reduce the formation of radical oxygen species leading to a dysfunction of protein repair and protein clearance, or to a formation of toxic byproducts accelerating neurodegeneration.
Keywords
Alzheimer's disease, oxidation, mitochondria, neurodegeneration, tau protein, ubiquitination
Pubmed
Web of science
Create date
23/07/2013 14:20
Last modification date
20/08/2019 16:21
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