Multipoint linkage mapping of the Xq25-q26 region in a family affected by the X-linked lymphoproliferative syndrome

Details

Serval ID
serval:BIB_B1CFC3D7D026
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Multipoint linkage mapping of the Xq25-q26 region in a family affected by the X-linked lymphoproliferative syndrome
Journal
Clinical Genetics
Author(s)
Sylla  B. S., Wang  Q., Hayoz  D., Lathrop  G. M., Lenoir  G. M.
ISSN
0009-9163 (Print)
Publication state
Published
Issued date
12/1989
Volume
36
Number
6
Pages
459-62
Notes
Journal Article --- Old month value: Dec
Abstract
We have performed, in a large Swiss family, a study of linkage between various DNA markers in the Xq24-27 region and the locus for the X-linked lymphoproliferative syndrome (XLP). Our results indicated that the marker DXS37 in Xq25-q26 is genetically linked to the XLP syndrome. The multipoint linkage analysis showed that the disease locus is distal to DXS11, but proximal to the hypoxanthine phosphoribosyl-transferase gene (HPRT).
Keywords
Female Genetic Markers Herpesvirus 4, Human/genetics Humans *Linkage (Genetics) *Lod Score Lymphoproliferative Disorders/*genetics Male Pedigree Polymorphism, Restriction Fragment Length Restriction Mapping *X Chromosome
Pubmed
Web of science
Create date
17/01/2008 16:38
Last modification date
20/08/2019 15:20
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