A genome-wide association study of neuroticism in a population-based sample.

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Serval ID
serval:BIB_B0C4E02333B9
Type
Article: article from journal or magazin.
Collection
Publications
Title
A genome-wide association study of neuroticism in a population-based sample.
Journal
Plos One
Author(s)
Calboli Federico C. F., Tozzi Federica, Galwey Nicholas W., Antoniades Athos, Mooser Vincent, Preisig Martin, Vollenweider Peter, Waterworth Dawn, Waeber Gerard, Johnson Michael R., Muglia Pierandrea, Balding David J.
ISSN
1932-6203[electronic], 1932-6203[linking]
Publication state
Published
Issued date
2010
Volume
5
Number
7
Pages
11504
Language
english
Abstract
Neuroticism is a moderately heritable personality trait considered to be a risk factor for developing major depression, anxiety disorders and dementia. We performed a genome-wide association study in 2,235 participants drawn from a population-based study of neuroticism, making this the largest association study for neuroticism to date. Neuroticism was measured by the Eysenck Personality Questionnaire. After Quality Control, we analysed 430,000 autosomal SNPs together with an additional 1.2 million SNPs imputed with high quality from the Hap Map CEU samples. We found a very small effect of population stratification, corrected using one principal component, and some cryptic kinship that required no correction. NKAIN2 showed suggestive evidence of association with neuroticism as a main effect (p < 10(-6)) and GPC6 showed suggestive evidence for interaction with age (p approximately = 10(-7)). We found support for one previously-reported association (PDE4D), but failed to replicate other recent reports. These results suggest common SNP variation does not strongly influence neuroticism. Our study was powered to detect almost all SNPs explaining at least 2% of heritability, and so our results effectively exclude the existence of loci having a major effect on neuroticism.
Keywords
Personality-Trait Neuroticism, Generalized Anxiety Disorder, Cardiovascular Risk-Factors, Major Depression, Linkage Analysis, Alzheimers-Disease, 1st Onset, Twin, Heritability, Genes , Colaus Study
Pubmed
Web of science
Open Access
Yes
Create date
26/07/2010 10:45
Last modification date
20/08/2019 16:19
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