Astrocyte Ca²⁺ signalling: an unexpected complexity.

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Serval ID
serval:BIB_B05989618118
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Astrocyte Ca²⁺ signalling: an unexpected complexity.
Journal
Nature Reviews. Neuroscience
Author(s)
Volterra A., Liaudet N., Savtchouk I.
ISSN
1471-0048 (Electronic)
ISSN-L
1471-003X
Publication state
Published
Issued date
05/2014
Peer-reviewed
Oui
Volume
15
Number
5
Pages
327-335
Language
english
Abstract
Astrocyte Ca(2+) signalling has been proposed to link neuronal information in different spatial-temporal dimensions to achieve a higher level of brain integration. However, some discrepancies in the results of recent studies challenge this view and highlight key insufficiencies in our current understanding. In parallel, new experimental approaches that enable the study of astrocyte physiology at higher spatial-temporal resolution in intact brain preparations are beginning to reveal an unexpected level of compartmentalization and sophistication in astrocytic Ca(2+) dynamics. This newly revealed complexity needs to be attentively considered in order to understand how astrocytes may contribute to brain information processing.
Keywords
Animals, Astrocytes/physiology, Astrocytes/ultrastructure, Brain/cytology, Calcium/metabolism, Calcium Signaling/physiology, Humans, Synapses/physiology
Pubmed
Web of science
Open Access
Yes
Create date
08/09/2014 13:04
Last modification date
20/08/2019 15:19
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