Cholangite biliaire primitive : mise à jour [Primary biliary cholangitis : an update]

Details

Serval ID
serval:BIB_B0081B423DB4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Cholangite biliaire primitive : mise à jour [Primary biliary cholangitis : an update]
Journal
Revue medicale suisse
Author(s)
Vieira Barbosa J., Vionnet J., Sciarra A., Sempoux C., Aubert V., Moradpour D., Fraga Christinet M.
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
29/08/2018
Peer-reviewed
Oui
Volume
14
Number
616
Pages
1489-1494
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Primary biliary cholangitis (PBC) is an autoimmune liver disease which affects primarily women and is characterized by progressive destruction of small intrahepatic bile ducts. Most common symptoms are fatigue and pruritus. Diagnostic hallmarks are cholestasis and positive antimitochondrial antibodies. The first-line therapy is ursodeoxycholic acid (UDCA), with excellent results when started at an early stage. Nevertheless, 30‑40 % of patients do not achieve a complete biochemical response with UDCA. In these cases, the adjunction of obeticholic acid can be discussed. Fibrates appear to be a promising alternative. Liver transplantation yields excellent outcomes in advanced cases.
Keywords
Autoimmune Diseases, Cholangitis/surgery, Female, Humans, Liver Cirrhosis, Biliary/surgery, Liver Transplantation, Ursodeoxycholic Acid
Pubmed
Create date
04/09/2018 9:19
Last modification date
20/08/2019 16:19
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