The expansion of amino-acid repeats is not associated to adaptive evolution in mammalian genes.

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Serval ID
serval:BIB_AE3C1C5E6707
Type
Article: article from journal or magazin.
Collection
Publications
Title
The expansion of amino-acid repeats is not associated to adaptive evolution in mammalian genes.
Journal
BMC Genomics
Author(s)
Cruz F., Roux J., Robinson-Rechavi M.
ISSN
1471-2164[electronic], 1471-2164[linking]
Publication state
Published
Issued date
2009
Peer-reviewed
Oui
Volume
10
Number
1
Pages
619
Language
english
Abstract
BACKGROUND: The expansion of amino acid repeats is determined by a high mutation rate and can be increased or limited by selection. It has been suggested that recent expansions could be associated with the potential of adaptation to new environments. In this work, we quantify the strength of this association, as well as the contribution of potential confounding factors. RESULTS: Mammalian positively selected genes have accumulated more recent amino acid repeats than other mammalian genes. However, we found little support for an accelerated evolutionary rate as the main driver for the expansion of amino acid repeats. The most significant predictors of amino acid repeats are gene function and GC content. There is no correlation with expression level. CONCLUSIONS: Our analyses show that amino acid repeat expansions are causally independent from protein adaptive evolution in mammalian genomes. Relaxed purifying selection or positive selection do not associate with more or more recent amino acid repeats. Their occurrence is slightly favoured by the sequence context but mainly determined by the molecular function of the gene.
Keywords
Animals, Base Composition, Comparative Genomic Hybridization, Evolution, Molecular, Gene Expression Profiling, Genome, Mammals/genetics, Models, Genetic, Repetitive Sequences, Amino Acid/genetics, Selection, Genetic, Sequence Alignment
Pubmed
Web of science
Open Access
Yes
Create date
04/12/2009 17:58
Last modification date
20/08/2019 16:18
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