Dose-dependent effect of atrial natriuretic peptide on blood pressure, heart rate, and skin blood flow of normal volunteers.

Details

Serval ID
serval:BIB_AD1030A96B17
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dose-dependent effect of atrial natriuretic peptide on blood pressure, heart rate, and skin blood flow of normal volunteers.
Journal
Journal of cardiovascular pharmacology
Author(s)
Bussien J.P., Biollaz J., Waeber B., Nussberger J., Turini G.A., Brunner H.R., Brunner-Ferber F., Gomez H.J., Otterbein E.S.
ISSN
0160-2446
Publication state
Published
Issued date
1986
Peer-reviewed
Oui
Volume
8
Number
1
Pages
216-20
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Synthetic atrial natriuretic peptide, containing 26 amino acids in the rat sequence, L-364, 343 (Ileu-ANP), was infused intravenously at increasing rates (1-40 micrograms/min) into four normal volunteers. Mean intraarterial blood pressure decreased and heart rate increased in cumulative-dose-dependent fashion. Skin blood flow as measured with a laser Doppler device rose already with a cumulative dose of 55 micrograms Ileu-ANP and further rises were directly related to dose. The only side effects observed were those accompanying symptomatic hypotension at higher doses. These findings provide strong evidence that Ileu-ANP acts as a vasodilator in normal volunteers.
Keywords
Adult, Atrial Natriuretic Factor, Blood Pressure, Heart Rate, Hemodynamics, Humans, Infusions, Parenteral, Male, Peptide Fragments, Regional Blood Flow, Skin
Pubmed
Web of science
Create date
05/03/2008 16:41
Last modification date
20/08/2019 15:17
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