Molecular cloning and expression of the human interferon-gamma receptor.

Details

Serval ID
serval:BIB_AC62603FA823
Type
Article: article from journal or magazin.
Collection
Publications
Title
Molecular cloning and expression of the human interferon-gamma receptor.
Journal
Cell
Author(s)
Aguet M., Dembić Z., Merlin G.
ISSN
0092-8674 (Print)
ISSN-L
0092-8674
Publication state
Published
Issued date
1988
Volume
55
Number
2
Pages
273-280
Language
english
Abstract
A cDNA encoding the human interferon-gamma receptor was isolated from a lambda gt11 expression library using a polyclonal antireceptor antiserum. The gene for this receptor was identified in a cosmid library and transfected into mouse cells. The human interferon-gamma receptor expressed in mouse cells displayed the same binding properties as in human cells. However, transfected cells were not sensitive to human IFN-gamma, suggesting the need for species-specific cofactors in receptor function. As inferred from the cDNA sequence, the human interferon-gamma receptor shows no similarities to known proteins and represents a novel transmembrane receptor. It is most likely the product of a single mRNA and a gene located on chromosome 6q.
Keywords
Amino Acid Sequence, Base Sequence, Cloning, Molecular, DNA/analysis, Gene Expression Regulation, Humans, Molecular Sequence Data, Molecular Weight, Receptors, Immunologic/genetics, Receptors, Interferon, Transfection
Pubmed
Web of science
Create date
28/01/2008 11:36
Last modification date
20/08/2019 15:16
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