Der EBNA2-codierende Bereich im viralen Genom Epstein-Barr Virus (EBV)-positiver Falle von Morbus Hodgkin. [The EBNA2 coding region in the viral genome of Epstein-Barr virus (EBV)-positive cases of Hodgkin's disease]
Details
Serval ID
serval:BIB_AACD3C92A551
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Der EBNA2-codierende Bereich im viralen Genom Epstein-Barr Virus (EBV)-positiver Falle von Morbus Hodgkin. [The EBNA2 coding region in the viral genome of Epstein-Barr virus (EBV)-positive cases of Hodgkin's disease]
Journal
Verhandlungen der Deutschen Gesellschaft fur Pathologie
ISSN
0070-4113 (Print)
Publication state
Published
Issued date
1992
Volume
76
Pages
181-4
Notes
Comparative Study
English Abstract
Journal Article
English Abstract
Journal Article
Abstract
Epstein-Barr virus (EBV)-genome containing cases of Hodgkin's disease (HD) are known to express latent membrane protein (LMP) of EBV but no EBV nuclear antigen 2 (EBNA2). We investigated 35 cases of HD for the presence of EBV genome sequences to know whether EBNA2 coding region is deleted in HD. 27 cases had general EBV sequences, none had evidence of a deletion of EBNA2. 26 cases turned out to harbour EBV type 1, one case had EBV type 2. The absence of EBNA2 protein expression in HD can not be explained by a deletion of EBNA2 coding region. EBV type 1 is the prevalent subtype of EBV in our series of HD.
Keywords
Acquired Immunodeficiency Syndrome/complications
Antigens, Viral/*genetics
Chromosome Mapping
DNA-Binding Proteins/*genetics
Epstein-Barr Virus Nuclear Antigens
*Genome, Viral
Herpesvirus 4, Human/*genetics/immunology/*isolation & purification
Hodgkin Disease/complications/*microbiology/pathology
Humans
Lymphoma, Non-Hodgkin/microbiology/pathology
Pubmed
Create date
25/01/2008 15:45
Last modification date
20/08/2019 16:14
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