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Der EBNA2-codierende Bereich im viralen Genom Epstein-Barr Virus (EBV)-positiver Falle von Morbus Hodgkin. [The EBNA2 coding region in the viral genome of Epstein-Barr virus (EBV)-positive cases of Hodgkin's disease]
Verhandlungen der Deutschen Gesellschaft fur Pathologie
Epstein-Barr virus (EBV)-genome containing cases of Hodgkin's disease (HD) are known to express latent membrane protein (LMP) of EBV but no EBV nuclear antigen 2 (EBNA2). We investigated 35 cases of HD for the presence of EBV genome sequences to know whether EBNA2 coding region is deleted in HD. 27 cases had general EBV sequences, none had evidence of a deletion of EBNA2. 26 cases turned out to harbour EBV type 1, one case had EBV type 2. The absence of EBNA2 protein expression in HD can not be explained by a deletion of EBNA2 coding region. EBV type 1 is the prevalent subtype of EBV in our series of HD.
Acquired Immunodeficiency Syndrome/complications Antigens, Viral/*genetics Chromosome Mapping DNA-Binding Proteins/*genetics Epstein-Barr Virus Nuclear Antigens *Genome, Viral Herpesvirus 4, Human/*genetics/immunology/*isolation & purification Hodgkin Disease/complications/*microbiology/pathology Humans Lymphoma, Non-Hodgkin/microbiology/pathology
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