BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis.

Details

Serval ID
serval:BIB_AA2899820A91
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis.
Journal
Clinical Infectious Diseases
Author(s)
Erard V., Storer B., Corey L., Nollkamper J., Huang M.L., Limaye A., Boeckh M.
ISSN
1537-6591[electronic]
Publication state
Published
Issued date
2004
Volume
39
Number
12
Pages
1861-1865
Language
english
Abstract
Blood samples from 132 consecutive hematopoietic stem cell transplant recipients were obtained and tested weekly for BK virus DNA by use of quantitative real-time PCR. Forty-four patients (33%) developed BK viremia at a median of 41 days (range, 9-91 days) after transplantation. Patients with hemorrhagic cystitis that occurred after platelet engraftment had higher levels of viremia than did patients without hemorrhagic cystitis (median, 9.7x10(3) vs. 0 copies/mL; P=.008) and patients with hemorrhagic cystitis that occurred before platelet engraftment (median, 9.7x10(3) vs. 0 copies/mL; P=.0006). BK viremia also was strongly associated with postengraftment hemorrhagic cystitis in a time-dependent analysis (P=.004).
Keywords
BK Virus, Cystitis/physiopathology, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation/adverse effects, Hematopoietic Stem Cells, Hemorrhage/physiopathology, Humans, Polyomavirus Infections/epidemiology, Polyomavirus Infections/physiopathology, Risk Factors
Pubmed
Web of science
Open Access
Yes
Create date
02/02/2010 18:11
Last modification date
20/08/2019 16:14
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