BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis.
Détails
ID Serval
serval:BIB_AA2899820A91
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
BK virus infection in hematopoietic stem cell transplant recipients: frequency, risk factors, and association with postengraftment hemorrhagic cystitis.
Périodique
Clinical infectious diseases
ISSN
1537-6591 (Electronic)
ISSN-L
1058-4838
Statut éditorial
Publié
Date de publication
15/12/2004
Peer-reviewed
Oui
Volume
39
Numéro
12
Pages
1861-1865
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Résumé
Blood samples from 132 consecutive hematopoietic stem cell transplant recipients were obtained and tested weekly for BK virus DNA by use of quantitative real-time PCR. Forty-four patients (33%) developed BK viremia at a median of 41 days (range, 9-91 days) after transplantation. Patients with hemorrhagic cystitis that occurred after platelet engraftment had higher levels of viremia than did patients without hemorrhagic cystitis (median, 9.7x10(3) vs. 0 copies/mL; P=.008) and patients with hemorrhagic cystitis that occurred before platelet engraftment (median, 9.7x10(3) vs. 0 copies/mL; P=.0006). BK viremia also was strongly associated with postengraftment hemorrhagic cystitis in a time-dependent analysis (P=.004).
Mots-clé
BK Virus, Cystitis/physiopathology, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation/adverse effects, Hematopoietic Stem Cells, Hemorrhage/physiopathology, Humans, Polyomavirus Infections/epidemiology, Polyomavirus Infections/physiopathology, Risk Factors
Pubmed
Web of science
Open Access
Oui
Création de la notice
02/02/2010 18:11
Dernière modification de la notice
10/02/2022 21:24
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