Simkania negevensis, an Example of the Diversity of the Antimicrobial Susceptibility Pattern among Chlamydiales.

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State: Public
Version: Final published version
Serval ID
serval:BIB_A96B1EBEB8DB
Type
Article: article from journal or magazin.
Collection
Publications
Title
Simkania negevensis, an Example of the Diversity of the Antimicrobial Susceptibility Pattern among Chlamydiales.
Journal
Antimicrobial agents and chemotherapy
Author(s)
Vouga M., Baud D., Greub G.
ISSN
1098-6596 (Electronic)
ISSN-L
0066-4804
Publication state
Published
Issued date
08/2017
Peer-reviewed
Oui
Volume
61
Number
8
Pages
1-5
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
In past years, several <i>Chlamydia</i> -related bacteria have been discovered, including <i>Simkania negevensis</i> , the founding member of the <i>Simkaniaceae</i> family. We evaluated the antimicrobial susceptibility patterns of this emerging intracellular bacterium and highlighted significant differences, compared with related <i>Chlamydiales</i> members. <i>S. negevensis</i> was susceptible to macrolides, clindamycin, cyclines, rifampin, and quinolones. Importantly, unlike other <i>Chlamydiales</i> members, treatment with β-lactams and vancomycin did not induce the formation of aberrant bodies, leading to a completely resistant phenotype.

Keywords
Animals, Anti-Bacterial Agents/pharmacology, Cell Line, Cercopithecus aethiops, Chlamydiaceae Infections, Chlamydiales/drug effects, Clindamycin/pharmacology, Macrolides/pharmacology, Microbial Sensitivity Tests, Quinolones/pharmacology, Rifampin/pharmacology, Vancomycin/pharmacology, Vero Cells, beta-Lactams/pharmacology, Chlamydiales, Simkaniaceae, intracellular bacteria
Pubmed
Web of science
Open Access
Yes
Create date
06/06/2017 18:16
Last modification date
20/08/2019 16:13
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