Diversity and regulatory impact of copy number variation in the primate Macaca fascicularis.

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State: Public
Version: Final published version
Serval ID
serval:BIB_A87ECF2238E9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Diversity and regulatory impact of copy number variation in the primate Macaca fascicularis.
Journal
BMC genomics
Author(s)
Gschwind A.R., Singh A., Certa U., Reymond A., Heckel T.
ISSN
1471-2164 (Electronic)
ISSN-L
1471-2164
Publication state
Published
Issued date
10/02/2017
Peer-reviewed
Oui
Volume
18
Number
1
Pages
144
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Copy number variations (CNVs) are a significant source of genetic diversity and commonly found in mammalian genomes. We have generated a genome-wide CNV map for Cynomolgus monkeys (Macaca fascicularis). This crab-eating macaque is the closest animal model to humans that is used in biomedical research.
We show that Cynomolgus monkey CNVs are in general much smaller in size than gene loci and are specific to the population of origin. Genome-wide expression data from five vitally important organs demonstrates that CNVs in close proximity to transcription start sites associate strongly with expression changes. Among these eQTL genes we find an overrepresentation of genes involved in metabolism, receptor activity, and transcription.
These results provide evidence that CNVs shape tissue transcriptomes in monkey populations, potentially offering an adaptive advantage. We suggest that this genetic diversity should be taken into account when using Cynomolgus macaques as models.

Keywords
Animals, DNA Copy Number Variations, Gene Expression Profiling, Genotype, Macaca fascicularis/genetics, Quantitative Trait Loci/genetics, CNV, Cynomolgus monkey, Gene expression, Olfactory receptors, eQTL
Pubmed
Web of science
Open Access
Yes
Create date
21/02/2017 20:10
Last modification date
20/08/2019 16:12
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