The 5th anniversary of "Patient Safety in Surgery" - from the Journal's origin to its future vision.

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State: Public
Version: author
Serval ID
serval:BIB_A7881477BA85
Type
Article: article from journal or magazin.
Publication sub-type
Editorial
Collection
Publications
Institution
Title
The 5th anniversary of "Patient Safety in Surgery" - from the Journal's origin to its future vision.
Journal
Patient Safety in Surgery
Author(s)
Stahel P.F., Smith W.R., Hahnloser D., Nigri G., Mauffrey C., Clavien P.A.
ISSN
1754-9493 (Electronic)
ISSN-L
1754-9493
Publication state
Published
Issued date
2012
Volume
6
Number
1
Pages
24
Language
english
Notes
Publication types: Journal ArticlePublication Status: epublish. PDF type: editorial
Abstract
A prospective study was undertaken to determine prognostic markers for patients with obstructive jaundice. Along with routine liver function tests, antipyrine clearance was determined in 20 patients. Four patients died after basal investigations. Five patients underwent definitive surgery. The remaining 11 patients were subjected to percutaneous transhepatic biliary decompression. Four patients died during the drainage period, while surgery was carried out for seven patients within 1-3 weeks of drainage. Of 20 patients, only six patients survived. Basal liver function tests were comparable in survivors and nonsurvivors. Discriminant analysis of the basal data revealed that plasma bilirubin, proteins and antipyrine half-life taken together had a strong association with mortality. A mathematical equation was derived using these variables and a score was computed for each patient. It was observed that a score value greater than or equal to 0.84 indicated survival. Omission of antipyrine half-life from the data, however, resulted in prediction of false security in 55% of patients. This study highlights the importance of addition of antipyrine elimination test to the routine liver function tests for precise identification of high risk patients.
Keywords
Adult, Aged, Antipyrine/pharmacokinetics, Cholestasis/metabolism, Cholestasis/mortality, Female, Humans, Liver/metabolism, Liver Function Tests/methods, Male, Middle Aged, Prognosis, Prospective Studies
Pubmed
Open Access
Yes
Create date
30/09/2014 14:23
Last modification date
20/08/2019 15:12
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