DX alpha gene polymorphism in Graves' disease

Details

Serval ID
serval:BIB_A6D227B38076
Type
Article: article from journal or magazin.
Collection
Publications
Title
DX alpha gene polymorphism in Graves' disease
Journal
Tissue Antigens
Author(s)
Weetman  A. P., Roe  C., So  A.
ISSN
0001-2815 (Print)
Publication state
Published
Issued date
01/1988
Volume
31
Number
1
Pages
1-4
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Abstract
An HLA-DX alpha gene polymorphism was analysed by Southern blotting in 49 British patients with Graves' disease and 61 control subjects. Two previously described allelic fragments of Taq I digested genomic DNA at 2.1 kb (U) and 1.9 kb (L) were found. The genotype frequencies for UU, UL and LL did not differ from the controls in Graves' disease, either for the whole groups or when subdivided into HLA-DR3-positive and -negative subjects. There was a significant association of the U allele with HLA-DR3 in both controls (P less than 0.05) and Graves' disease (P less than 0.025). The results indicate that DX alpha polymorphism is not primarily associated with Graves' disease. The findings differ from recent studies which showed that DX alpha polymorphisms may contribute to susceptibility in other DR3-associated autoimmune diseases.
Keywords
Alleles Genotype Graves Disease/*genetics HLA-D Antigens/*genetics Humans *Polymorphism, Genetic Polymorphism, Restriction Fragment Length
Pubmed
Web of science
Create date
25/01/2008 9:39
Last modification date
03/03/2018 20:18
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