DX alpha gene polymorphism in Graves' disease

Détails

ID Serval
serval:BIB_A6D227B38076
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
DX alpha gene polymorphism in Graves' disease
Périodique
Tissue Antigens
Auteur(s)
Weetman  A. P., Roe  C., So  A.
ISSN
0001-2815 (Print)
Statut éditorial
Publié
Date de publication
01/1988
Volume
31
Numéro
1
Pages
1-4
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Résumé
An HLA-DX alpha gene polymorphism was analysed by Southern blotting in 49 British patients with Graves' disease and 61 control subjects. Two previously described allelic fragments of Taq I digested genomic DNA at 2.1 kb (U) and 1.9 kb (L) were found. The genotype frequencies for UU, UL and LL did not differ from the controls in Graves' disease, either for the whole groups or when subdivided into HLA-DR3-positive and -negative subjects. There was a significant association of the U allele with HLA-DR3 in both controls (P less than 0.05) and Graves' disease (P less than 0.025). The results indicate that DX alpha polymorphism is not primarily associated with Graves' disease. The findings differ from recent studies which showed that DX alpha polymorphisms may contribute to susceptibility in other DR3-associated autoimmune diseases.
Mots-clé
Alleles Genotype Graves Disease/*genetics HLA-D Antigens/*genetics Humans *Polymorphism, Genetic Polymorphism, Restriction Fragment Length
Pubmed
Web of science
Création de la notice
25/01/2008 9:39
Dernière modification de la notice
03/03/2018 20:18
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