Electrical colonic stimulation reduces mean transit time in a porcine model.

Details

Serval ID
serval:BIB_A51AC6060FA2
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Electrical colonic stimulation reduces mean transit time in a porcine model.
Journal
Neurogastroenterology and motility
Author(s)
Vaucher J., Cerantola Y., Gie O., Letovanec I., Virag N., Demartines N., Gardaz J.P., Givel J.C.
ISSN
1365-2982[electronic]
Publication state
Published
Issued date
2010
Volume
22
Pages
88-92, e31
Language
english
Abstract
Abstract Electrical stimulation is a new way to treat digestive disorders such as constipation. Colonic propulsive activity can be triggered by battery operated devices. This study aimed to demonstrate the effect of direct electrical colonic stimulation on mean transit time in a chronic porcine model. The impact of stimulation and implanted material on the colonic wall was also assessed. Three pairs of electrodes were implanted into the caecal wall of 12 anaesthetized pigs. Reference colonic transit time was determined by radiopaque markers for each pig before implantation. It was repeated 4 weeks after implantation with sham stimulation and 5 weeks after implantation with electrical stimulation. Aboral sequential trains of 1-ms pulse width (10 V; 120 Hz) were applied twice daily for 6 days, using an external battery operated stimulator. For each course of markers, a mean value was computed from transit times obtained from individual pig. Microscopic examination of the caecum was routinely performed after animal sacrifice. A reduction of mean transit time was observed after electrical stimulation (19 +/- 13 h; mean +/- SD) when compared to reference (34 +/- 7 h; P = 0.045) and mean transit time after sham stimulation (36 +/- 9 h; P = 0.035). Histological examination revealed minimal chronic inflammation around the electrodes. Colonic transit time measured in a chronic porcine model is reduced by direct sequential electrical stimulation. Minimal tissue lesion is elicited by stimulation or implanted material. Electrical colonic stimulation could be a promising approach to treat specific disorders of the large bowel.
Pubmed
Web of science
Create date
01/10/2009 9:24
Last modification date
20/08/2019 15:10
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