Endocan concentrations in postmortem serum, vitreous humor and urine in victims of lethal hypothermia.

Details

Serval ID
serval:BIB_A4FEB58F8AAA
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Endocan concentrations in postmortem serum, vitreous humor and urine in victims of lethal hypothermia.
Journal
Journal of forensic and legal medicine
Author(s)
Descloux E., Augsburger M., Teresiński G., Hejna P., Grouzmann E., Scarpelli M.P., Hervet T., Palmiere C.
ISSN
1878-7487 (Electronic)
ISSN-L
1752-928X
Publication state
Published
Issued date
08/2017
Peer-reviewed
Oui
Volume
50
Pages
39-43
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Endocan is a soluble molecule secreted from vascular endothelial cells of various organs. Its exact function in humans remains to be elucidated, though it has been postulated that increased tissue expression or serum levels of this molecule may be an indicator of endothelial activation and neovascularization. In the realm of forensic pathology, studies pertaining to endothelial activation following exposure to cold exclusively focused on thrombomodulin, a transmembrane protein specific to endothelial cells. In the study herein described, endocan concentrations were determined in postmortem serum, urine and vitreous humor samples collected during autopsy in a series of cases that underwent medicolegal investigations. A total of 76 autopsy cases were selected and three study groups (hypothermia group, sepsis group and non-hypothermia/non-sepsis group) prospectively formed during the study period. The obtained results seem to indicate that exposure to cold and subsequent death is not distinguished by significant endothelial dysfunction causing enhanced endocan secretion.

Keywords
Autopsy, Endocan, Endothelium, Hypothermia, Postmortem biochemistry, Postmortem serum, Urine, Vitreous humor
Pubmed
Web of science
Open Access
Yes
Create date
17/07/2017 9:49
Last modification date
20/08/2019 16:10
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