A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings.

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Serval ID
serval:BIB_A4BE81144959
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A review of methods for assessment of coronary microvascular disease in both clinical and experimental settings.
Journal
Cardiovascular Research
Author(s)
Pries A.R., Habazettl H., Ambrosio G., Hansen P.R., Kaski J.C., Schächinger V., Tillmanns H., Vassalli G., Tritto I., Weis M., de Wit C., Bugiardini R.
ISSN
0008-6363
Publication state
Published
Issued date
2008
Peer-reviewed
Oui
Volume
80
Number
2
Pages
165-174
Language
english
Abstract
Obstructive disease of the large coronary arteries is the prominent cause for angina pectoris. However, angina may also occur in the absence of significant coronary atherosclerosis or coronary artery spasm, especially in women. Myocardial ischaemia in these patients is often associated with abnormalities of the coronary microcirculation and may thus represent a manifestation of coronary microvascular disease (CMD). Elucidation of the role of the microvasculature in the genesis of myocardial ischaemia and cardiac damage-in the presence or absence of obstructive coronary atherosclerosis-will certainly result in more rational diagnostic and therapeutic interventions for patients with ischaemic heart disease. Specifically targeted research based on improved assessment modalities is needed to improve the diagnosis of CMD and to translate current molecular, cellular, and physiological knowledge into new therapeutic options.
Keywords
Angina Pectoris/etiology, Angina Pectoris/physiopathology, Animals, Coronary Circulation, Coronary Disease/complications, Coronary Disease/diagnosis, Diagnostic Techniques, Cardiovascular, Disease Models, Animal, Endothelium, Vascular/physiopathology, Humans, Microcirculation, Myocardial Ischemia/etiology, Myocardial Ischemia/physiopathology
Pubmed
Web of science
Open Access
Yes
Create date
15/10/2009 8:02
Last modification date
25/09/2019 6:10
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