A European multicentre prospective randomized study to assess the use of assisted hatching with a diode laser and the benefit of an immunosuppressive/antibiotic treatment in different patient populations

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Serval ID
serval:BIB_A4BBC0CBB357
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A European multicentre prospective randomized study to assess the use of assisted hatching with a diode laser and the benefit of an immunosuppressive/antibiotic treatment in different patient populations
Journal
Human Reproduction (oxford, England)
Author(s)
Primi M.P., Senn A., Montag M., Van der Ven H., Mandelbaum J., Veiga A., Barri P., Germond M.
ISSN
0268-1161 (Print)
ISSN-L
0268-1161
Publication state
Published
Issued date
2004
Volume
19
Number
10
Pages
2325-2333
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
Publication Status: ppublish
Abstract
BACKGROUND: Assisted hatching (AH) techniques, designed for facilitating the embryo escape out of the zona pellucida (ZP) have been used in IVF centres since 1992. The initial indications for AH were patient's age, ZP thickness, high basal FSH and repeated IVF failures. Several retrospective and prospective studies assessing AH in these indications have given disparate results. Our aims were to evaluate the benefits of AH and immunosuppressive/antibiotic treatment (IA) in patients with either a poor prognosis of success, previous implantation failures or transfers of cryopreserved embryos.
METHODS: Four IVF centres allocated 426 patients, randomized for AH and IA, into four groups of AH indications between 1997 and 1999. AH was performed with a diode laser. ZP thickness, opening size and embryo score were recorded. Outcome measures were implantation and delivery rates.
RESULTS: Patients coming for a first or third transfer of cryopreserved embryos and poor prognosis patients admitted for a first trial did not benefit from AH. Even patients with repeated implantation failures of fresh embryos did not gain significantly from AH.
CONCLUSIONS: Among AH indications, absence of implantation after several transfers of good quality embryos remains the strongest patient selection criterion. Prescription of an immunosuppressive/antibiotic treatment is essential.
Keywords
Anti-Bacterial Agents/therapeutic use, Immunosuppressive Agents/therapeutic use, Zona Pellucida/radiation effects
Pubmed
Web of science
Open Access
Yes
Create date
13/07/2018 9:00
Last modification date
01/10/2019 6:19
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