Jonctions communicantes et sécrétion [Gap junctions and secretion]

Details

Serval ID
serval:BIB_A46A7300E1E3
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Jonctions communicantes et sécrétion [Gap junctions and secretion]
Journal
Revue médicale suisse
Author(s)
Haefliger J.A., Allagnat F., Krattinger N., Martin D., Waeber G., Nicod P., Meda P.
ISSN
1660-9379
Publication state
Published
Issued date
2005
Volume
1
Number
17
Pages
1134-9
Language
french
Notes
Publication types: English Abstract ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review - Publication Status: ppublish
Abstract
The emergence of multicellular organisms has necessitated the development of mechanisms for interactions between adjacent and distant cells. A consistent feature of this network is the expression of gap junction channels between the secretory cells of all glands so far investigated in vertebrates. Here, we reviewed the distribution of the gap junctions proteins, named connexins, in a few mammalian glands, and discussed the recent evidence pointing to the participation of these proteins in the functioning of endocrine and exocrine cells. Specifically, available data indicate the importance of gap junctions for the proper control of glucose-induced insulin secretion. Understanding the functions of beta-cell connexins are crucial for the engineering of surrogate cells, which is necessary for implementation of a replacement cell therapy in diabetic patients.
Keywords
Animals, Connexins, Endocrine System, Gap Junctions, Humans, Islets of Langerhans
Pubmed
Create date
25/01/2008 14:48
Last modification date
20/08/2019 16:09
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