Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry database (ICAD).

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_A42734C97DC1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children's Accelerometry database (ICAD).
Journal
The international journal of behavioral nutrition and physical activity
Author(s)
Wijndaele K., White T., Andersen L.B., Bugge A., Kolle E., Northstone K., Wedderkopp N., Ried-Larsen M., Kriemler S., Page A.S., Puder J.J., Reilly J.J., Sardinha L.B., van Sluijs EMF, Sharp S.J., Brage S., Ekelund U.
Working group(s)
International Children's Accelerometry Database (ICAD) Collaborators
Contributor(s)
Andersen L.B., Anderssen S., Atkin A.J., Cardon G., Davey R., Ekelund U., Esliger D.W., Hallal P., Hansen B.H., Janz K.F., Kriemler S., Møller N., Northstone K., Page A., Pate R., Puder J.J., Reilly J.J., Salmon J., Sardinha L.B., Sherar L.B., Timperio A., van Sluijs EMF
ISSN
1479-5868 (Electronic)
ISSN-L
1479-5868
Publication state
Published
Issued date
31/10/2019
Peer-reviewed
Oui
Volume
16
Number
1
Pages
96
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Evidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorous physical activity (MVPA) in children.
Cross-sectional data from 14 studies (7 countries) in the International Children's Accelerometry Database (ICAD, 1998-2009) was included. Accelerometry in 19,502 participants aged 3-18 years, together with covariate and outcome data, was pooled and harmonized. Iso-temporal substitution in linear regression models provided beta coefficients (95%CI) for substitution of 1 h/day PST (sedentary time accumulated in bouts > 15 min) with non-PST, LIPA or MVPA, for each study, which were meta-analysed.
Modelling substitution of 1 h/day of PST with non-PST suggested reductions in standardized BMI, but estimates were > 7-fold greater for substitution with MVPA (- 0.44 (- 0.62; - 0.26) SD units). Only reallocation by MVPA was beneficial for waist circumference (- 3.07 (- 4.47; - 1.68) cm), systolic blood pressure (- 1.53 (- 2.42; - 0.65) mmHg) and clustered cardio-metabolic risk (- 0.18 (- 0.3; - 0.1) SD units). For HDL-cholesterol and diastolic blood pressure, substitution with LIPA was beneficial; however, substitution with MVPA showed 5-fold stronger effect estimates (HDL-cholesterol: 0.05 (0.01; 0.10) mmol/l); diastolic blood pressure: - 0.81 (- 1.38; - 0.24) mmHg).
Replacement of PST with MVPA may be the preferred scenario for behaviour change, given beneficial associations with a wide range of cardio-metabolic risk factors (including adiposity, HDL-cholesterol, blood pressure and clustered cardio-metabolic risk). Effect estimates are clinically relevant (e.g. an estimated reduction in waist circumference of ≈1.5 cm for 30 min/day replacement). Replacement with LIPA could be beneficial for some of these risk factors, however with substantially lower effect estimates.
Keywords
Accelerometry, Adolescent, Blood Pressure/physiology, Cardiovascular Diseases/epidemiology, Child, Child, Preschool, Cholesterol, HDL/blood, Cross-Sectional Studies, Exercise/physiology, Humans, Risk Factors, Sedentary Behavior, Waist Circumference/physiology, ALSPAC, Cardio-metabolic, ICAD, Iso-temporal, Physical activity, Prolonged sitting
Pubmed
Web of science
Open Access
Yes
Funding(s)
Swiss National Science Foundation
Create date
02/11/2019 22:50
Last modification date
18/02/2020 6:20
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