Advances and Applications in the Quest for Orthologs.

Details

Serval ID
serval:BIB_A36FE75880A9
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Advances and Applications in the Quest for Orthologs.
Journal
Molecular biology and evolution
Author(s)
Glover N., Dessimoz C., Ebersberger I., Forslund S.K., Gabaldón T., Huerta-Cepas J., Martin M.J., Muffato M., Patricio M., Pereira C., da Silva A.S., Wang Y., Sonnhammer E., Thomas P.D.
Contributor(s)
Altenhoff A., Blake J.A., Capella-Gutierrez S., Chiba H., Dessimoz C., Durand D., Ebersberger I., Tomás Fernández-Breis J., Forslund S., Gabaldon T., Glover N., Huerta-Cepas J., Lecompte O., Lewis S., Linard B., Marcet Houben M., Marcotte E.M., Martin M.J., McWhite C., Mendes de Farias T., Muffato M., Nevers Y., Patricio M., Pereira C., Pryszcz L., Saha S., Schiffer P., Sonnhammer E., Sousa da Silva A., Tang H., Thomas P.D., Uchiyama I., Wang Y.
ISSN
1537-1719 (Electronic)
ISSN-L
0737-4038
Publication state
Published
Issued date
01/10/2019
Peer-reviewed
Oui
Volume
36
Number
10
Pages
2157-2164
Language
english
Notes
Publication types: Congress ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Gene families evolve by the processes of speciation (creating orthologs), gene duplication (paralogs), and horizontal gene transfer (xenologs), in addition to sequence divergence and gene loss. Orthologs in particular play an essential role in comparative genomics and phylogenomic analyses. With the continued sequencing of organisms across the tree of life, the data are available to reconstruct the unique evolutionary histories of tens of thousands of gene families. Accurate reconstruction of these histories, however, is a challenging computational problem, and the focus of the Quest for Orthologs Consortium. We review the recent advances and outstanding challenges in this field, as revealed at a symposium and meeting held at the University of Southern California in 2017. Key advances have been made both at the level of orthology algorithm development and with respect to coordination across the community of algorithm developers and orthology end-users. Applications spanned a broad range, including gene function prediction, phylostratigraphy, genome evolution, and phylogenomics. The meetings highlighted the increasing use of meta-analyses integrating results from multiple different algorithms, and discussed ongoing challenges in orthology inference as well as the next steps toward improvement and integration of orthology resources.
Keywords
Algorithms, Animals, Evolution, Molecular, Genomics/methods, Genomics/trends, Humans, Multigene Family, gene family, genome evolution, orthology
Pubmed
Web of science
Open Access
Yes
Create date
08/07/2019 17:09
Last modification date
11/01/2020 7:16
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