Human innate lymphoid cells (ILCs): Toward a uniform immune-phenotyping.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_A2FB75F5FD09
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Human innate lymphoid cells (ILCs): Toward a uniform immune-phenotyping.
Journal
Cytometry. Part B, Clinical cytometry
Author(s)
Trabanelli S., Gomez-Cadena A., Salomé B., Michaud K., Mavilio D., Landis B.N., Jandus P., Jandus C.
ISSN
1552-4957 (Electronic)
ISSN-L
1552-4949
Publication state
Published
Issued date
05/2018
Peer-reviewed
Oui
Volume
94
Number
3
Pages
392-399
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Helper innate lymphoid cells (ILCs), the most recently identified population of the ILC family, play a fundamental role in the restoration of tissue integrity, in the protection against infiltrating pathogens as well as in tumor immune-surveillance. ILCs have been divided into three main subsets, ILC1, ILC2, and ILC3, that can be specifically activated by different signals coming either indirectly from pathogens or from other cell populations, including cancer cells. Following activation, ILCs are in turn able to promptly secrete a wide range of soluble mediators that modulate effector cell functions. The discovery and the study of these immune cells is now offering important opportunities for innovative therapies of allergic airway diseases, inflammatory disorders and might be crucial for the discovery of new targets for the therapy of cancer. It is therefore fundamental that the scientific community establishes harmonized guidelines to obtain a consensus in the identification and phenotypical and functional characterization of ILCs. © 2018 International Clinical Cytometry Society.
Keywords
Animals, Flow Cytometry/methods, Humans, Immunity, Innate/immunology, Immunologic Factors/immunology, Immunophenotyping/methods, Lymphocytes/immunology, allergy, flow cytometry, immune monitoring, innate lymphoid cells, leukemia, phenotype
Pubmed
Web of science
Create date
26/04/2018 13:22
Last modification date
20/08/2019 15:08
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