The SLC2 (GLUT) family of membrane transporters.

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Serval ID
serval:BIB_A2607C275E16
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The SLC2 (GLUT) family of membrane transporters.
Journal
Molecular Aspects of Medicine
Author(s)
Mueckler M., Thorens B.
ISSN
1872-9452 (Electronic)
ISSN-L
0098-2997
Publication state
Published
Issued date
2013
Peer-reviewed
Oui
Volume
34
Number
2-3
Pages
121-138
Language
english
Abstract
GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human and they are categorized into three classes based on sequence similarity. All GLUTs appear to transport hexoses or polyols when expressed ectopically, but the primary physiological substrates for several of the GLUTs remain uncertain. GLUTs 1-5 are the most thoroughly studied and all have well established roles as glucose and/or fructose transporters in various tissues and cell types. The GLUT proteins are comprised of ∼500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 membrane-spanning domains. In this review we briefly describe the major characteristics of the 14 GLUT family members.
Keywords
SLC2, GLUT, Membrane transport, Glucose transporters, Glucose homeostasis
Pubmed
Web of science
Open Access
Yes
Create date
30/05/2013 13:15
Last modification date
20/08/2019 15:08
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