Therapeutic cancer vaccines based on molecularly defined human tumor antigens.

Details

Serval ID
serval:BIB_A1891852C369
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Therapeutic cancer vaccines based on molecularly defined human tumor antigens.
Journal
Vaccine
Author(s)
Romero P., Pittet M., Dutoit V., Zippelius A., Liénard D., Lejeune F., Guillaume P., Rimoldi D., Valmori D., Speiser D.E., Cerottini J.C.
ISSN
0264-410X
Publication state
Published
Issued date
2002
Peer-reviewed
Oui
Volume
20 Suppl 4
Pages
A2-7
Language
english
Notes
Publication types: Journal Article - Publication Status: ppublish
Abstract
The results of numerous phases I and II clinical trials testing the safety and immunogenicity of various cancer vaccine formulations based on cytolytic T lymphocytes (CTLs)-defined tumor antigens have been reported recently. Specific T cell responses can be detected in only a fraction of immunized patients. A smaller but significant fraction of these patients have objective tumor responses. Efficient therapeutic vaccination should aim at boosting naturally occurring anti-tumor responses and at sustaining a large contingent of tumor antigen-specific and fully functional effector T cells at tumor sites.
Keywords
Antigens, Neoplasm, Cancer Vaccines, Clinical Trials, Phase I as Topic, Clinical Trials, Phase II as Topic, Humans, T-Lymphocytes, Cytotoxic
Pubmed
Web of science
Create date
28/01/2008 11:14
Last modification date
20/08/2019 15:07
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