Effects of traumatic brain injury on the cholinergic system in the rat

Details

Serval ID
serval:BIB_9CE364933A4E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effects of traumatic brain injury on the cholinergic system in the rat
Journal
Journal of Neurotrauma
Author(s)
Gorman  L. K., Fu  K., Hovda  D. A., Murray  M., Traystman  R. J.
ISSN
0897-7151
Publication state
Published
Issued date
08/1996
Peer-reviewed
Oui
Volume
13
Number
8
Pages
457-63
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Abstract
Rats subjected to a mild to moderate fluid percussion injury exhibit memory deficits that are similar to rats that have received lesions of the septohippocampal system. Because the cholinergic system plays a major role in septohippocampal function, we studied the kinetics of the synthetic enzyme for acetylcholine, choline acetyltransferase (ChAT), at 1 h, 24 h, or 5 days after a fluid percussion injury. Decreases in ChAT activity were found in the dorsal hippocampus (25%), frontal (32%), and temporal (23%) cortices 1 h after injury. In the parietal cortex, a greater than 50% increase in ChAT activity was observed at all time intervals assessed. At 5 days after TBI, there was an 18% increase in ChAT activity in the medial septal area. These data provide evidence that a mild to moderate fluid percussion injury produces changes in the cholinergic system in brain areas related to memory.
Keywords
Analysis of Variance Animals Brain/*enzymology/physiology/physiopathology Brain Injuries/*enzymology/physiopathology Cerebellum/enzymology Choline O-Acetyltransferase/*metabolism Entorhinal Cortex/enzymology Frontal Lobe/enzymology Hippocampus/enzymology Kinetics Male Memory/physiology Occipital Lobe/enzymology Organ Specificity Parietal Lobe/enzymology Rats Rats, Sprague-Dawley Temporal Lobe/enzymology Time Factors
Pubmed
Web of science
Create date
21/01/2008 10:23
Last modification date
20/08/2019 15:03
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