Effects of traumatic brain injury on the cholinergic system in the rat
Détails
ID Serval
serval:BIB_9CE364933A4E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effects of traumatic brain injury on the cholinergic system in the rat
Périodique
Journal of Neurotrauma
ISSN
0897-7151
Statut éditorial
Publié
Date de publication
08/1996
Peer-reviewed
Oui
Volume
13
Numéro
8
Pages
457-63
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Résumé
Rats subjected to a mild to moderate fluid percussion injury exhibit memory deficits that are similar to rats that have received lesions of the septohippocampal system. Because the cholinergic system plays a major role in septohippocampal function, we studied the kinetics of the synthetic enzyme for acetylcholine, choline acetyltransferase (ChAT), at 1 h, 24 h, or 5 days after a fluid percussion injury. Decreases in ChAT activity were found in the dorsal hippocampus (25%), frontal (32%), and temporal (23%) cortices 1 h after injury. In the parietal cortex, a greater than 50% increase in ChAT activity was observed at all time intervals assessed. At 5 days after TBI, there was an 18% increase in ChAT activity in the medial septal area. These data provide evidence that a mild to moderate fluid percussion injury produces changes in the cholinergic system in brain areas related to memory.
Mots-clé
Analysis of Variance
Animals
Brain/*enzymology/physiology/physiopathology
Brain Injuries/*enzymology/physiopathology
Cerebellum/enzymology
Choline O-Acetyltransferase/*metabolism
Entorhinal Cortex/enzymology
Frontal Lobe/enzymology
Hippocampus/enzymology
Kinetics
Male
Memory/physiology
Occipital Lobe/enzymology
Organ Specificity
Parietal Lobe/enzymology
Rats
Rats, Sprague-Dawley
Temporal Lobe/enzymology
Time Factors
Pubmed
Web of science
Création de la notice
21/01/2008 11:23
Dernière modification de la notice
20/08/2019 16:03