Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.

Details

Ressource 1Download: BIB_9CE30F110D2A.P001.pdf (882.85 [Ko])
State: Public
Version: Final published version
Serval ID
serval:BIB_9CE30F110D2A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.
Journal
Bmj Open
Author(s)
Morris R.W., Taylor A.E., Fluharty M.E., Bjørngaard J.H., Åsvold B.O., Elvestad Gabrielsen M., Campbell A., Marioni R., Kumari M., Korhonen T., Männistö S., Marques-Vidal P., Kaakinen M., Cavadino A., Postmus I., Husemoen L.L., Skaaby T., Ahluwalia T.V., Treur J.L., Willemsen G., Dale C., Wannamethee S.G., Lahti J., Palotie A., Räikkönen K., McConnachie A., Padmanabhan S., Wong A., Dalgård C., Paternoster L., Ben-Shlomo Y., Tyrrell J., Horwood J., Fergusson D.M., Kennedy M.A., Nohr E.A., Christiansen L., Kyvik K.O., Kuh D., Watt G., Eriksson J.G., Whincup P.H., Vink J.M., Boomsma D.I., Davey Smith G., Lawlor D., Linneberg A., Ford I., Jukema J.W., Power C., Hyppönen E., Jarvelin M.R., Preisig M., Borodulin K., Kaprio J., Kivimaki M., Smith B.H., Hayward C., Romundstad P.R., Sørensen T.I., Munafò M.R., Sattar N.
ISSN
2044-6055 (Electronic)
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
5
Number
8
Pages
e008808
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: epublish
Abstract
OBJECTIVES: To investigate, using a Mendelian randomisation approach, whether heavier smoking is associated with a range of regional adiposity phenotypes, in particular those related to abdominal adiposity.
DESIGN: Mendelian randomisation meta-analyses using a genetic variant (rs16969968/rs1051730 in the CHRNA5-CHRNA3-CHRNB4 gene region) as a proxy for smoking heaviness, of the associations of smoking heaviness with a range of adiposity phenotypes.
PARTICIPANTS: 148,731 current, former and never-smokers of European ancestry aged ≥ 16 years from 29 studies in the consortium for Causal Analysis Research in Tobacco and Alcohol (CARTA).
PRIMARY OUTCOME MEASURES: Waist and hip circumferences, and waist-hip ratio.
RESULTS: The data included up to 66,809 never-smokers, 43,009 former smokers and 38,913 current daily cigarette smokers. Among current smokers, for each extra minor allele, the geometric mean was lower for waist circumference by -0.40% (95% CI -0.57% to -0.22%), with effects on hip circumference, waist-hip ratio and body mass index (BMI) being -0.31% (95% CI -0.42% to -0.19), -0.08% (-0.19% to 0.03%) and -0.74% (-0.96% to -0.51%), respectively. In contrast, among never-smokers, these effects were higher by 0.23% (0.09% to 0.36%), 0.17% (0.08% to 0.26%), 0.07% (-0.01% to 0.15%) and 0.35% (0.18% to 0.52%), respectively. When adjusting the three central adiposity measures for BMI, the effects among current smokers changed direction and were higher by 0.14% (0.05% to 0.22%) for waist circumference, 0.02% (-0.05% to 0.08%) for hip circumference and 0.10% (0.02% to 0.19%) for waist-hip ratio, for each extra minor allele.
CONCLUSIONS: For a given BMI, a gene variant associated with increased cigarette consumption was associated with increased waist circumference. Smoking in an effort to control weight may lead to accumulation of central adiposity.
Keywords
Adolescent, Adult, Aged, Body Mass Index, Female, Humans, Male, Mendelian Randomization Analysis, Middle Aged, Obesity, Abdominal/complications, Sex Factors, Smoking/adverse effects, Smoking/genetics, Waist Circumference, Waist-Hip Ratio, Young Adult
Pubmed
Web of science
Open Access
Yes
Create date
28/08/2015 16:00
Last modification date
20/08/2019 16:03
Usage data