Function and mechanism of the pyrin inflammasome.

Details

Serval ID
serval:BIB_9CB85942D08B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Function and mechanism of the pyrin inflammasome.
Journal
European journal of immunology
Author(s)
Heilig R., Broz P.
ISSN
1521-4141 (Electronic)
ISSN-L
0014-2980
Publication state
Published
Issued date
02/2018
Peer-reviewed
Oui
Volume
48
Number
2
Pages
230-238
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
Pyrin, encoded by the MEFV gene, is an intracellular pattern recognition receptor that assembles inflammasome complexes in response to pathogen infections. Mutations in the MEFV gene have been linked to autoinflammatory diseases such as familial Mediterranean fever (FMF) or pyrin-associated autoinflammation with neutrophilic dermatosis (PAAND). Recent insights have now revealed how pyrin is activated during infection, providing a molecular basis for the understanding of such disease-causing mutations in pyrin. Interestingly, pyrin does not directly recognize molecular patterns (pathogen- or host-derived danger molecules), but rather responds to disturbances in cytoplasmic homeostasis caused by the infection. In the case of pyrin, these perturbations, recently defined as 'homeostasis-altering molecular processes' (HAMPs), are processes leading to the inactivation of the RhoA GTPase. This review attempts to combine early observation and findings with the most recent discoveries on how pyrin detects inactivation of RhoA to shed light on the function and mechanism of pyrin activation.
Keywords
Animals, Familial Mediterranean Fever/genetics, Familial Mediterranean Fever/immunology, Homeostasis, Humans, Infection/genetics, Infection/immunology, Inflammasomes/metabolism, Pyrin/genetics, Pyroptosis, Sweet Syndrome/genetics, Sweet Syndrome/immunology, rhoA GTP-Binding Protein/metabolism, FMF, Inflammasome, MEFV, Pyrin
Pubmed
Web of science
Create date
23/11/2017 21:16
Last modification date
20/08/2019 15:03
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