The alpha1b-adrenergic receptor subtype: molecular properties and physiological implications.

Details

Serval ID
serval:BIB_9CA1E92EC32E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The alpha1b-adrenergic receptor subtype: molecular properties and physiological implications.
Journal
Journal of Receptor and Signal Transduction Research
Author(s)
Cotecchia S., Björklöf K., Rossier O., Stanasila L., Greasley P., Fanelli F.
ISSN
1079-9893 (Print)
ISSN-L
1079-9893
Publication state
Published
Issued date
2002
Volume
22
Number
1-4
Pages
1-16
Language
english
Abstract
The aim of this review is to summarize some of the main findings from our laboratory as well as from others concerning the biochemical, molecular, and functional properties of the alpha1b-adrenergic receptor. Experimental and computational mutagenesis of the alpha1b-adrenergic receptor have been instrumental in elucidating some of the molecular mechanisms underlying receptor activation and receptor coupling to Gq. The knockout mouse model lacking the alpha1b-adrenergic receptor has highlighted the potential implication of this receptor subtype in variety of functions including the regulation of blood pressure, glucose homeostasis, and the rewarding response to drugs of abuse.
Keywords
Adrenergic alpha-Agonists/pharmacology, Animals, Blood Pressure/drug effects, Blood Pressure/physiology, Glucose/metabolism, Homeostasis, Humans, Mice, Mice, Knockout, Phosphorylation, Receptors, Adrenergic, alpha-1/physiology, Signal Transduction
Pubmed
Web of science
Create date
24/01/2008 11:05
Last modification date
20/08/2019 15:03
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