A comparison of cold storage solutions for pancreas preservation prior to islet isolation.

Details

Serval ID
serval:BIB_9BFFC13C0C17
Type
Article: article from journal or magazin.
Collection
Publications
Title
A comparison of cold storage solutions for pancreas preservation prior to islet isolation.
Journal
Transplantation proceedings
Author(s)
Wojtusciszyn A., Bosco D., Morel P., Baertschiger R., Armanet M., Kempf M.C., Badet L., Toso C., Berney T.
ISSN
0041-1345 (Print)
ISSN-L
0041-1345
Publication state
Published
Issued date
10/2005
Peer-reviewed
Oui
Volume
37
Number
8
Pages
3396-3397
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Abstract
Several solutions are used to preserve the pancreas prior to islet isolation. This study sought to assess whether the type of solution had an impact on the isolation outcome.
We reviewed data from 125 islet isolation procedures performed from January 2002 to January 2005. Pancreata were preserved in University of Wisconsin (UW) (n = 101), Celsior (CS) (n = 19), or IGL-1 (n = 5) solutions. Islet isolation results and transplantation rates were compared between groups.
UW, CS, and IGL-1 groups were similar according to donor's age, weight, and body mass index. Weight of undigested pancreas was 20 +/- 13.1, 21.4 +/- 15.7, and 17.4 +/- 8.7 g for UW, CS, and IGL-1, respectively (P > .2). Final total number of IEQ was 267,000 +/- 132,000, 277,000 +/- 155,000, and 311,000 +/- 163,000, respectively (P > .4). Success rate (defined as >250,000 IEQ) was 55.5%, 52.9%, and 60% for UW, Celsior, and IGL-1 (P > .9); the transplantation rate was 42.2% for UW, 36.8% for Celsior, and 80% for IGL-1 preservation (P > .2).
In this preliminary study, UW, Celsior, and IGL-1 solutions demonstrated similar islet isolation results. The new IGL-1 solution appears promising.
Keywords
Adenosine, Allopurinol, Disaccharides, Electrolytes, Glutamates, Glutathione, Histidine, Humans, Insulin, Islets of Langerhans/cytology, Islets of Langerhans Transplantation, Mannitol, Organ Preservation Solutions, Pancreas, Raffinose, Tissue and Organ Harvesting/methods
Pubmed
Web of science
Create date
14/06/2021 9:59
Last modification date
24/05/2024 11:53
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