New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.

Details

Serval ID
serval:BIB_9BEFC7CAA18D
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
Journal
Nature Genetics
Author(s)
Horikoshi M., Yaghootkar H., Mook-Kanamori D.O., Sovio U., Taal H.R., Hennig B.J., Bradfield J.P., St Pourcain B., Evans D.M., Charoen P., Kaakinen M., Cousminer D.L., Lehtimäki T., Kreiner-Møller E., Warrington N.M., Bustamante M., Feenstra B., Berry D.J., Thiering E., Pfab T., Barton S.J., Shields B.M., Kerkhof M., van Leeuwen E.M., Fulford A.J., Kutalik Z., Zhao J.H., den Hoed M., Mahajan A., Lindi V., Goh L.K., Hottenga J.J., Wu Y., Raitakari O.T., Harder M.N., Meirhaeghe A., Ntalla I., Salem R.M., Jameson K.A., Zhou K., Monies D.M., Lagou V., Kirin M., Heikkinen J., Adair L.S., Alkuraya F.S., Al-Odaib A., Amouyel P., Andersson E.A., Bennett A.J., Blakemore A.I., Buxton J.L., Dallongeville J., Das S., de Geus E.J., Estivill X., Flexeder C., Froguel P., Geller F., Godfrey K.M., Gottrand F., Groves C.J., Hansen T., Hirschhorn J.N., Hofman A., Hollegaard M.V., Hougaard D.M., Hyppönen E., Inskip H.M., Isaacs A., Jørgensen T., Kanaka-Gantenbein C., Kemp J.P., Kiess W., Kilpeläinen T.O., Klopp N., Knight B.A., Kuzawa C.W., McMahon G., Newnham J.P., Niinikoski H., Oostra B.A., Pedersen L., Postma D.S., Ring S.M., Rivadeneira F., Robertson N.R., Sebert S., Simell O., Slowinski T., Tiesler C.M., Tönjes A., Vaag A., Viikari J.S., Vink J.M., Vissing N.H., Wareham N.J., Willemsen G., Witte D.R., Zhang H., Zhao J., Meta-Analyses of Glucose-, Wilson J.F., Wilson J.F., Stumvoll M., Prentice A.M., Meyer B.F., Pearson E.R., Boreham C.A., Cooper C., Gillman M.W., Dedoussis G.V., Moreno L.A., Pedersen O., Saarinen M., Mohlke K.L., Boomsma D.I., Saw S.M., Lakka T.A., Körner A., Loos R.J., Ong K.K., Vollenweider P., van Duijn C.M., Koppelman G.H., Hattersley A.T., Holloway J.W., Hocher B., Heinrich J., Power C., Melbye M., Guxens M., Pennell C.E., Bønnelykke K., Bisgaard H., Eriksson J.G., Widén E., Hakonarson H., Uitterlinden A.G., Pouta A., Lawlor D.A., Smith G.D., Frayling T.M., McCarthy M.I., Grant S.F., Jaddoe V.W., Jarvelin M.R., Timpson N.J., Prokopenko I., Freathy R.M.
Working group(s)
Insulin-related traits Consortium (MAGIC), Early Growth Genetics (EGG) Consortium
Contributor(s)
Meta-Analyses of Glucose-
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Publication state
Published
Issued date
12/2013
Volume
45
Number
1
Pages
76-82
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
Publication Status: ppublish. PDF type: article
Abstract
Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.
Keywords
Adult, Birth Weight/genetics, Blood Pressure/genetics, Body Height/genetics, Diabetes Mellitus, Type 2/genetics, Female, Fetal Development/genetics, Genetic Linkage, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Infant, Newborn, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Quantitative Trait Loci
Pubmed
Create date
10/01/2013 11:56
Last modification date
20/08/2019 15:02
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