Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons

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State: Public
Version: Final published version
Serval ID
serval:BIB_9B972D023A05
Type
Article: article from journal or magazin.
Collection
Publications
Title
Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons
Journal
Cell reports
Author(s)
Bartolini G., Sánchez-Alcañiz J. A, Osório C., Valiente M., García-Frigola C, Marín O.
ISSN
2211-1247 (Electronic)
Publication state
Published
Issued date
2017
Peer-reviewed
Oui
Volume
18
Number
5
Pages
1157-1170
Language
english
Abstract
Neural circuits in the cerebral cortex consist of excitatory pyramidal cells and inhibitory interneurons. These two main classes of cortical neurons follow largely different genetic programs, yet they assemble into highly specialized circuits during development following a very precise choreography. Previous studies have shown that signals produced by pyramidal cells influence the migration of cortical interneurons, but the molecular nature of these factors has remained elusive. Here, we identified Neuregulin 3 (Nrg3) as a chemoattractive factor expressed by developing pyramidal cells that guides the allocation of cortical interneurons in the developing cortical plate. Gain- and loss-of-function approaches reveal that Nrg3 modulates the migration of interneurons into the cortical plate in a process that is dependent on the tyrosine kinase receptor ErbB4. Perturbation of Nrg3 signaling in conditional mutants leads to abnormal lamination of cortical interneurons. Nrg3 is therefore a critical mediator in the assembly of cortical inhibitory circuits.
Pubmed
Web of science
Open Access
Yes
Create date
10/04/2017 10:02
Last modification date
20/08/2019 16:02
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