Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes.

Details

Serval ID
serval:BIB_9AE098AB1330
Type
Article: article from journal or magazin.
Collection
Publications
Title
Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes.
Journal
Diabetes Care
Author(s)
D'Addio F., Maffi P., Vezzulli P., Vergani A., Mello A., Bassi R., Nano R., Falautano M., Coppi E., Finzi G., D'Angelo A., Fermo I., Pellegatta F., La Rosa S., Magnani G., Piemonti L., Falini A., Folli F., Secchi A., Fiorina P.
ISSN
1935-5548 (Electronic)
ISSN-L
0149-5992
Publication state
Published
Issued date
2014
Peer-reviewed
Oui
Volume
37
Number
1
Pages
267-276
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
OBJECTIVE Islets after kidney transplantation have been shown to positively affect the quality of life of individuals with type 1 diabetes (T1D) by reducing the burden of diabetes complications, but fewer data are available for islet transplantation alone (ITA). The aim of this study was to assess whether ITA has a positive impact on hemostatic and cerebral abnormalities in individuals with T1D. RESEARCH DESIGN AND METHODS Prothrombotic factors, platelet function/ultrastructure, and cerebral morphology, metabolism, and function have been investigated over a 15-month follow-up period using ELISA/electron microscopy and magnetic resonance imaging, nuclear magnetic resonance spectroscopy, and neuropsychological evaluation (Profile of Mood States test and paced auditory serial addition test) in 22 individuals with T1D who underwent ITA (n = 12) or remained on the waiting list (n = 10). Patients were homogeneous with regard to metabolic criteria, hemostatic parameters, and cerebral morphology/metabolism/function at the time of enrollment on the waiting list. RESULTS At the 15-month follow-up, the group undergoing ITA, but not individuals with T1D who remained on the waiting list, showed 1) improved glucose metabolism; 2) near-normal platelet activation and prothrombotic factor levels; 3) near-normal cerebral metabolism and function; and 4) a near-normal neuropsychological test. CONCLUSIONS ITA, despite immunosuppressive therapy, is associated with a near-normalization of hemostatic and cerebral abnormalities.
Keywords
Adult, Blood Glucose/metabolism, Blood Platelets/pathology, Blood Platelets/physiology, Brain/metabolism, Brain/pathology, Diabetes Mellitus, Type 1/pathology, Diabetes Mellitus, Type 1/physiopathology, Female, Hemostasis, Humans, Immunosuppressive Agents/therapeutic use, Islets of Langerhans Transplantation, Male, Pilot Projects, Quality of Life, Retrospective Studies
Pubmed
Web of science
Open Access
Yes
Create date
06/09/2016 13:51
Last modification date
20/08/2019 16:01
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