Nonvascularized human skin chronic allograft rejection.

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Version: Author's accepted manuscript
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Serval ID
serval:BIB_99FA1291AC19
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Nonvascularized human skin chronic allograft rejection.
Journal
American journal of transplantation
Author(s)
Rotman S., Koch N., Wiesner L., Aubert V., Rosales I.A., Colvin R.B., Raffoul W., Pascual M.
ISSN
1600-6143 (Electronic)
ISSN-L
1600-6135
Publication state
Published
Issued date
11/2019
Peer-reviewed
Oui
Volume
19
Number
11
Pages
3191-3196
Language
english
Notes
Publication types: Case Reports
Publication Status: ppublish
Abstract
A 65-year-old man had extensive burns of the lower legs in 1991, at the age of 40 years. He was treated by nonvascularized and de-epithelialized, allogeneic split-thickness skin allograft and cyclosporine monotherapy for 2 months. Ulcers developed between 10 and 25 years after transplantation and a surgical debridement on the lower extremities was required. Analyses of the removed tissue allografts showed chronic antibody-mediated and cellular rejection with extensive and dense fibrosis, and diffuse capillary C4d deposits. An anti-DRB1*08:01, donor-specific antibody was present. A unique clinical condition with late immunopathological features of human skin chronic allograft rejection is reported.
Keywords
accommodation, alloantibody, clinical research/practice, ethics and public policy, organ transplantation in general, pathology/histopathology, rejection: antibody-mediated (ABMR), surgical technique, tolerance, vascularized composite and reconstructive transplantation
Pubmed
Web of science
Create date
26/07/2019 14:28
Last modification date
10/12/2019 7:17
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