Lymphoepithelioma-Like Carcinoma in Liver.

Details

Serval ID
serval:BIB_99BC15E3E680
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Lymphoepithelioma-Like Carcinoma in Liver.
Journal
The American journal of pathology
Author(s)
Labgaa I., Stueck A., Ward S.C.
ISSN
1525-2191 (Electronic)
ISSN-L
0002-9440
Publication state
Published
Issued date
07/2017
Peer-reviewed
Oui
Volume
187
Number
7
Pages
1438-1444
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Liver cancer, primarily encompassing hepatocellular carcinoma and intrahepatic cholangiocarcinoma, has become the second leading cause of worldwide cancer-related death during the past two decades. Lymphoepithelioma-like carcinomas (LELCs) are defined as tumors composed of undifferentiated epithelial cells with a prominent lymphoid infiltrate, and can arise in the liver as hepatocellular or cholangiocarcinoma forms. Patients with liver LELC display distinctive demographics and tumor characteristics. LELCs also appear to be associated with strikingly better outcomes compared to typical liver cancers, with 5-year survival rates of 57% to 100% versus 12% to 68%, respectively. Liver LELCs represent a unique model of immune response in liver cancer. Data on LELCs of the liver remain limited, and future comprehensive studies are needed to further elucidate this disease, which could ultimately offer precious insights for immunotherapeutic strategies in liver cancer.

Pubmed
Web of science
Create date
23/05/2017 17:59
Last modification date
20/08/2019 16:01
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