Lymphoepithelioma-Like Carcinoma in Liver.

Détails

ID Serval
serval:BIB_99BC15E3E680
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Lymphoepithelioma-Like Carcinoma in Liver.
Périodique
The American journal of pathology
Auteur⸱e⸱s
Labgaa I., Stueck A., Ward S.C.
ISSN
1525-2191 (Electronic)
ISSN-L
0002-9440
Statut éditorial
Publié
Date de publication
07/2017
Peer-reviewed
Oui
Volume
187
Numéro
7
Pages
1438-1444
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Liver cancer, primarily encompassing hepatocellular carcinoma and intrahepatic cholangiocarcinoma, has become the second leading cause of worldwide cancer-related death during the past two decades. Lymphoepithelioma-like carcinomas (LELCs) are defined as tumors composed of undifferentiated epithelial cells with a prominent lymphoid infiltrate, and can arise in the liver as hepatocellular or cholangiocarcinoma forms. Patients with liver LELC display distinctive demographics and tumor characteristics. LELCs also appear to be associated with strikingly better outcomes compared to typical liver cancers, with 5-year survival rates of 57% to 100% versus 12% to 68%, respectively. Liver LELCs represent a unique model of immune response in liver cancer. Data on LELCs of the liver remain limited, and future comprehensive studies are needed to further elucidate this disease, which could ultimately offer precious insights for immunotherapeutic strategies in liver cancer.

Pubmed
Web of science
Création de la notice
23/05/2017 17:59
Dernière modification de la notice
13/12/2022 7:48
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