Effect of added dead space on sleep disordered breathing at high altitude.

Details

Serval ID
serval:BIB_982119C059D5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effect of added dead space on sleep disordered breathing at high altitude.
Journal
Sleep Medicine
Author(s)
Lovis A., De Riedmatten M., Greiner D., Lecciso G., Andries D., Scherrer U., Wellman A., Sartori C., Heinzer R.
ISSN
1878-5506 (Electronic)
ISSN-L
1389-9457
Publication state
Published
Issued date
2012
Volume
13
Number
6
Pages
663-667
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish
Abstract
OBJECTIVE: Sleep disordered breathing with central apnea or hypopnea frequently occurs at high altitude and is thought to be caused by a decrease in blood CO(2) level. The aim of this study was to assess the effects of added respiratory dead space on sleep disordered breathing.¦METHODS: Full polysomnographies were performed on 12 unacclimatized swiss mountaineers (11 males, 1 female, mean age 39±12 y.o.) in Leh, Ladakh (3500m). In random order, half of the night was spent with a 500ml increase in dead space through a custom designed full face mask and the other half without it.¦RESULTS: Baseline data revealed two clearly distinct groups: one with severe sleep disordered breathing (n=5, AHI>30) and the other with moderate to no disordered breathing (n=7, AHI<30). DS markedly improved breathing in the first group (baseline vs DS): apnea hypopnea index (AHI) 70.3±25.8 vs 29.4±6.9 (p=0.013), oxygen desaturation index (ODI): 72.9±24.1/h vs 42.5±14.4 (p=0.031), whereas it had no significant effect in the second group or in the total population. Respiratory events were almost exclusively central apnea or hypopnea. Microarousal index, sleep efficiency, and sleep architecture remained unchanged with DS. A minor increase in mean PtcCO(2) (n=3) was observed with DS.¦CONCLUSION: A 500ml increase in dead space through a fitted mask may improve nocturnal breathing in mountaineers with severe altitude-induced sleep disordered breathing.
Pubmed
Web of science
Create date
02/08/2012 19:09
Last modification date
20/08/2019 15:59
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